Contamination control is of great importance to healthcare facilities and to pharmaceutical cleanrooms. One way of ensuring the hygiene is maintained through a cleaning and disinfection regime. After a disinfectant has been chosen based on its chemical properties and expected performance/effectiveness, each disinfectant should be validated to ensure its efficacy.

For the purpose of protecting pharmaceuticals from contamination with microbes or nonviable particles filling and closing machinery are equipped with isolators or other barrier systems. It is not only the Sterility Assurance Level (SAL) which is focused upon but also the non-productive time for decontamination processes between batches which has to be taken into account.
This article describes and evaluates a new technology to reduce the cycle time of isolators.

What performance requirements are needed for analytical procedures to ensure an alignment with the enhanced approach of Quality by Design for product/process?
An analytical procedure should be followed during the life cycle of the product to continually assure that it remains fit for its intended purpose.

A platform process is a production process suitable for the manufacture of a group of related products in a defined production system. At Lonza one of our technology offerings is a platform process for the production of therapeutic proteins in Chinese hamster ovary (CHO) cells.